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Comment
. 2013 Mar 5;17(3):311-2.
doi: 10.1016/j.cmet.2013.02.014.

Novel SIRT1 mutation linked to autoimmune diabetes in humans

Jing W Hughes  1 , Kevan C Herold
Affiliations
Comment

Novel SIRT1 mutation linked to autoimmune diabetes in humans

Jing W Hughes et al. Cell Metab. .

Abstract

Sirtuins are best known for their role in aging but also regulate many different biological processes. A study in this issue of Cell Metabolism (Biason-Lauber et al., 2013) now identifies a mutation in human SIRT1 causing a familial form of autoimmune diabetes.

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Figures

Figure 1
Figure 1. SIRT1 Regulation of Lymphocytes and β Cells in Autoimmune Diabetes
SIRT1 as a transcriptional regulator controls multiple cellular processes and signaling pathways that differentially affect the immune system and pancreatic β cells. A familial mutation in the SIRT1 protein renders affected individuals susceptible toward autoimmune diabetes and inflammatory bowel disease, highlighting a role for SIRT1 in regulating development of autoimmune disease.
See this image and copyright information in PMC

Comment on

  • Identification of a SIRT1 mutation in a family with type 1 diabetes.
    Biason-Lauber A, Böni-Schnetzler M, Hubbard BP, Bouzakri K, Brunner A, Cavelti-Weder C, Keller C, Meyer-Böni M, Meier DT, Brorsson C, Timper K, Leibowitz G, Patrignani A, Bruggmann R, Boily G, Zulewski H, Geier A, Cermak JM, Elliott P, Ellis JL, Westphal C, Knobel U, Eloranta JJ, Kerr-Conte J, Pattou F, Konrad D, Matter CM, Fontana A, Rogler G, Schlapbach R, Regairaz C, Carballido JM, Glaser B, McBurney MW, Pociot F, Sinclair DA, Donath MY. Biason-Lauber A, et al. Cell Metab. 2013 Mar 5;17(3):448-455. doi: 10.1016/j.cmet.2013.02.001. Cell Metab. 2013. PMID: 23473037 Free PMC article.

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