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. 1975 Jan;32(1):47-9.
doi: 10.1001/archneur.1975.00490430069012.

Postmortem changes in brain catecholamine enzymes

I B Black, S C Geen

Postmortem changes in brain catecholamine enzymes

I B Black et al. Arch Neurol. 1975 Jan.

Abstract

Postmortem changes in the activities of tyrosine hydroxylase, dopa decarboxylase, and dopamine-beta-hydroxylase were examined in various areas of rat brain. Tyrosine hydroxylase activity decreased in an exponential fashion with a half-time of two to four hours in caudate-putamen, substantia nigra, and locus ceruleus. Dopa decarboxylase activity remained within 20% of control values at five hours in these areas, but then decreased precipitously. Dopamine-beta-hydroxylase activity remained within 20% of control for at least 20 hours after death.

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