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Review
. 2013 Apr;154(4):511-514.
doi: 10.1016/j.pain.2013.02.002. Epub 2013 Feb 13.

Placebo analgesia: psychological and neurobiological mechanisms

Luana Colloca  1 , Regine Klinger, Herta Flor, Ulrike Bingel
Affiliations
Review

Placebo analgesia: psychological and neurobiological mechanisms

Luana Colloca et al. Pain. 2013 Apr.
No abstract available

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Conflict of interest statement

Conflict of interests: The authors have not conflicts of interest to declare.

Figures

Figure 1
Figure 1
Psychological mechanisms such as verbally-induced expectations, cued and contextual conditioning and social learning trigger the cascade of endogenous opioids and non-opioids. The result is an alteration of the pain experience that at least in part, induces an active inhibition of nociceptive activity and modulation of brain areas predicting placebo analgesic responses. PFC, prefrontal cortex; ACC, anterior cingulate cortex; SI, primary somatosensory cortex; SII secondary somatosensory cortex; PAG, periacqueductal gray.
See this image and copyright information in PMC

Comment in

  • Pain beyond biology.
    Avila LA. Avila LA. Pain. 2013 Nov;154(11):2571-2572. doi: 10.1016/j.pain.2013.07.003. Epub 2013 Jul 9. Pain. 2013. PMID: 23850424 No abstract available.
  • Response to the letter to the editor by L.A. Avila.
    Colloca L, Klinger R, Flor H, Bingel U. Colloca L, et al. Pain. 2013 Nov;154(11):2572. doi: 10.1016/j.pain.2013.06.048. Epub 2013 Aug 21. Pain. 2013. PMID: 23973360 No abstract available.

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