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Comment
. 2013 Nov;22(9):2625-9.
doi: 10.1007/s11136-013-0385-x. Epub 2013 Mar 10.

Pitfalls in subgroup analysis based on growth mixture models: a commentary on Van Leeuwen et al. (2012)

Cameron N McIntosh  1
Affiliations
Comment

Pitfalls in subgroup analysis based on growth mixture models: a commentary on Van Leeuwen et al. (2012)

Cameron N McIntosh. Qual Life Res. 2013 Nov.

Abstract

Objectives: This article is a brief commentary in response to "van Leeuwen et al. (Qual Life Res 21:1499-1508, 2012)"

Methods and results: The commentary argues that in the context of mixture modeling, assigning individuals to specific subgroups for conducting a secondary set of analyses ignores the original uncertainty in group membership, thereby biasing any subsequent results and inference.

Conclusions: Alternative approaches to subgroup analysis that attempt to preserve uncertainty in group membership are discussed and illustrated.

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