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. 2014 Feb;71(2):458-68.
doi: 10.1002/mrm.24703.

ProFit revisited

Alexander Fuchs  1 , Peter Boesiger, Rolf F Schulte, Anke Henning
Affiliations
Free article

ProFit revisited

Alexander Fuchs et al. Magn Reson Med. 2014 Feb.
Free article

Abstract

Purpose: An enhanced version of the ProFit fitting tool was developed and validated to improve the quantification of two-dimensional JRPESS spectroscopic data.

Methods: The proposed enhancements were achieved by flexible organization of prior knowledge, configurations for different situations, the inclusion of measured macromolecular baseline contribution, additional baseline splines and a model-free lineshape based on self-deconvolution. The new software was tested and tuned on simulated data and subsequently applied to in vivo intrasubject and intersubject data.

Results: Fit results of simulated and acquired spectra show good overall quality suggesting the potential reliable detection of up to 18 metabolites on a 3T system yielding Cramer-Lower-Bounds below 20%.

Conclusion: The proposed enhanced version of ProFit together with two-dimensional J-resolved spectroscopy offers the opportunity to reliably detect a wide selection of important brain metabolites on 3T.

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