Early replication fragile sites may underlie gene rearrangements

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Comment

No authors listed. Cancer Discov. 2013 Mar.

. 2013 Mar;3(3):OF11.

doi: 10.1158/2159-8290.CD-RW2013-026. Epub 2013 Jan 31.

Abstract

Replication stress can induce spontaneous breakage of early replication fragile sites (ERFS).

Identification of early replicating fragile sites that contribute to genome instability.
Barlow JH, Faryabi RB, Callén E, Wong N, Malhowski A, Chen HT, Gutierrez-Cruz G, Sun HW, McKinnon P, Wright G, Casellas R, Robbiani DF, Staudt L, Fernandez-Capetillo O, Nussenzweig A. Barlow JH, et al. Cell. 2013 Jan 31;152(3):620-32. doi: 10.1016/j.cell.2013.01.006. Epub 2013 Jan 24. Cell. 2013. PMID: 23352430 Free PMC article. Review.