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Comment
. 2013 Mar;3(3):OF13.
doi: 10.1158/2159-8290.CD-RW2013-028. Epub 2013 Feb 7.

SMO and AKT1 mutations occur in non-NF2 meningiomas

No authors listed
Comment

SMO and AKT1 mutations occur in non-NF2 meningiomas

No authors listed. Cancer Discov. 2013 Mar.

Abstract

Recurrent mutations in SMO and AKT1 are mutually exclusive with NF2 loss in meningioma.

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Comment on

  • Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations.
    Brastianos PK, Horowitz PM, Santagata S, Jones RT, McKenna A, Getz G, Ligon KL, Palescandolo E, Van Hummelen P, Ducar MD, Raza A, Sunkavalli A, Macconaill LE, Stemmer-Rachamimov AO, Louis DN, Hahn WC, Dunn IF, Beroukhim R. Brastianos PK, et al. Nat Genet. 2013 Mar;45(3):285-9. doi: 10.1038/ng.2526. Epub 2013 Jan 20. Nat Genet. 2013. PMID: 23334667 Free PMC article.
  • Genomic analysis of non-NF2 meningiomas reveals mutations in TRAF7, KLF4, AKT1, and SMO.
    Clark VE, Erson-Omay EZ, Serin A, Yin J, Cotney J, Ozduman K, Avşar T, Li J, Murray PB, Henegariu O, Yilmaz S, Günel JM, Carrión-Grant G, Yilmaz B, Grady C, Tanrikulu B, Bakircioğlu M, Kaymakçalan H, Caglayan AO, Sencar L, Ceyhun E, Atik AF, Bayri Y, Bai H, Kolb LE, Hebert RM, Omay SB, Mishra-Gorur K, Choi M, Overton JD, Holland EC, Mane S, State MW, Bilgüvar K, Baehring JM, Gutin PH, Piepmeier JM, Vortmeyer A, Brennan CW, Pamir MN, Kiliç T, Lifton RP, Noonan JP, Yasuno K, Günel M. Clark VE, et al. Science. 2013 Mar 1;339(6123):1077-80. doi: 10.1126/science.1233009. Epub 2013 Jan 24. Science. 2013. PMID: 23348505 Free PMC article.

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