The tumor suppressor FAT1 modulates WNT activity in multiple cancers

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Comment

No authors listed. Cancer Discov. 2013 Mar.

. 2013 Mar;3(3):OF19.

doi: 10.1158/2159-8290.CD-RW2013-031. Epub 2013 Feb 7.

Abstract

FAT1 is a tumor suppressor that is frequently mutated and inhibits WNT/β-catenin signaling.

Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation.
Morris LG, Kaufman AM, Gong Y, Ramaswami D, Walsh LA, Turcan Ş, Eng S, Kannan K, Zou Y, Peng L, Banuchi VE, Paty P, Zeng Z, Vakiani E, Solit D, Singh B, Ganly I, Liau L, Cloughesy TC, Mischel PS, Mellinghoff IK, Chan TA. Morris LG, et al. Nat Genet. 2013 Mar;45(3):253-61. doi: 10.1038/ng.2538. Epub 2013 Jan 27. Nat Genet. 2013. PMID: 23354438 Free PMC article.