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. 2013:2013:360190.
doi: 10.1155/2013/360190. Epub 2013 Feb 17.

Plasma progranulin concentrations are increased in patients with type 2 diabetes and obesity and correlated with insulin resistance

Hua Qu  1 , Huacong Deng, Zhenping Hu
Affiliations

Plasma progranulin concentrations are increased in patients with type 2 diabetes and obesity and correlated with insulin resistance

Hua Qu et al. Mediators Inflamm. 2013.

Abstract

Insulin resistance (IR) is considered to be one of the most important pathogenesis of glycolipid metabolism disorders. However, the molecular mechanism responsible for IR is not fully understood. Recently, the chronic inflammation has been proposed to be involved in the pathogenesis of IR. In this study, we aim to investigate the concentrations of plasma progranulin in Chinese patients with obesity (OB) and type 2 diabetes mellitus (T2DM), and its relationship to IR. Plasma progranulin concentrations were significantly higher in the T2DM patients than in the normal glucose tolerant (NGT) subjects (P < 0.01). Within the T2DM and the NGT patients, the concentrations of progranulin were significantly higher in obese subjects than that in the normal weight subjects (225.22 ± 34.39 ng/mL versus 195.59 ± 50.47 ng/mL and 183.79 ± 61.63 ng/mL versus 148.69 ± 55.27 ng/mL, P < 0.05). Plasma progranulin concentrations correlated positively with weight, waist circumferences, BMI, HbA1c, TG, IL-6, FINS and HOMA-IR (P < 0.05), while correlated negatively with HOMA- β (P < 0.05). Multiple linear regression analysis showed that BMI, HbA1c, IL-6 and TG correlated independently with circulating progranulin concentrations (P < 0.05). These results suggested that Plasma progranulin concentrations were higher in Chinese patients with type 2 diabetes and obesity and correlated closely with glycolipid metabolism, chronic inflammation and IR.

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Figures

Figure 1
Figure 1
Plasma PGRN levels in different groups. Data are presented as means ± SD.  a P < 0.01 compared with NGT;  b P < 0.05 compared with NGT-NW;  c P < 0.01 compared with NGT-NW;  d P < 0.01 compared with NGT-OB;  e P < 0.05 compared with T2DM-NW.
Figure 2
Figure 2
Scatter plots showing the correlation of plasma PGRN levels with HOMA-IR and HOMA-β in all subjects. (a) The plasma PGRN levels positively correlated with HOMA-IR. (b) The plasma PGRN levels negatively correlated with HOMA-β.
See this image and copyright information in PMC

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