doi: 10.1152/jappl.1990.68.4.1755.
Xanthine oxidase is increased and contributes to paraquat-induced acute lung injury
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- PMID: 2347813
- DOI: 10.1152/jappl.1990.68.4.1755
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Xanthine oxidase is increased and contributes to paraquat-induced acute lung injury
J Appl Physiol (1985).
1990 Apr.
Abstract
Two lines of investigation suggested that xanthine oxidase- (XO) derived O2 metabolites contribute to paraquat- (PQ) induced acute lung injury. First, PQ treatment increased lung XO activity and decreased lung xanthine dehydrogenase activity. Second, lung albumin uptake increased compared with control values in untreated XO-replete but not tungsten-treated XO-depleted lungs in rats treated with PQ.
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