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. 1990 Apr;68(4):1755-7.
doi: 10.1152/jappl.1990.68.4.1755.

Xanthine oxidase is increased and contributes to paraquat-induced acute lung injury

M L Waintrub  1 , L S Terada, C J Beehler, B O Anderson, J A Leff, J E Repine
Affiliations

Xanthine oxidase is increased and contributes to paraquat-induced acute lung injury

M L Waintrub et al. J Appl Physiol (1985). 1990 Apr.

Abstract

Two lines of investigation suggested that xanthine oxidase- (XO) derived O2 metabolites contribute to paraquat- (PQ) induced acute lung injury. First, PQ treatment increased lung XO activity and decreased lung xanthine dehydrogenase activity. Second, lung albumin uptake increased compared with control values in untreated XO-replete but not tungsten-treated XO-depleted lungs in rats treated with PQ.

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