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. 2013 Apr;10(4):183-4.
doi: 10.1038/nrcardio.2013.28. Epub 2013 Mar 12.

Pharmacotherapy: Optimal blockade of the renin-angiotensin-aldosterone system

Jürg Nussberger  1 , Jürgen Bohlender
Affiliations

Pharmacotherapy: Optimal blockade of the renin-angiotensin-aldosterone system

Jürg Nussberger et al. Nat Rev Cardiol. 2013 Apr.

Abstract

Inhibition of the renin–angiotensin–aldosterone system (RAAS) is a successful therapy for hypertension, heart failure, and renal insufficiency. Overdosing of RAAS inhibitors is occasionally observed when several agents are used together, and can cause adverse events such as hypotension, hyperkalaemia, and renal failure. We advocate optimal, rather than complete, RAAS blockade.

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