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Comment
. 2013 May;23(5):597-8.
doi: 10.1038/cr.2013.38. Epub 2013 Mar 12.

Proteasome-independent p53 degradation

Mais M Nuaaman  1 , Samuel Benchimol
Affiliations
Comment

Proteasome-independent p53 degradation

Mais M Nuaaman et al. Cell Res. 2013 May.

Abstract

The intracellular levels of the p53 tumor suppressor protein are regulated through various pathways and involve numerous regulatory components. A recent study published in Cell Research identifies a proteasome-independent pathway of p53 protein degradation in the nucleolus that is dependent on Def and Calpain3.

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