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Comparative Study
. 2013 Jun;14(2):569-77.
doi: 10.1208/s12249-013-9941-5. Epub 2013 Mar 13.

Solid-state characterization and dissolution properties of meloxicam-moringa coagulant-PVP ternary solid dispersions

Suhail B Noolkar  1 , Namdeo R Jadhav, Santosh A Bhende, Suresh G Killedar
Affiliations
Comparative Study

Solid-state characterization and dissolution properties of meloxicam-moringa coagulant-PVP ternary solid dispersions

Suhail B Noolkar et al. AAPS PharmSciTech. 2013 Jun.

Abstract

The effect of ternary solid dispersions of poor water-soluble NSAID meloxicam with moringa coagulant (obtained by salt extraction of moringa seeds) and polyvinylpyrrolidone on the in vitro dissolution properties has been investigated. Binary (meloxicam-moringa and meloxicam-polyvinylpyrrolidone (PVP)) and ternary (meloxicam-moringa-PVP) systems were prepared by physical kneading and ball milling and characterized by Fourier transform infrared spectroscopy, differential scanning calorimetry, and X-ray diffractometry. The in vitro dissolution behavior of meloxicam from the different products was evaluated by means of United States Pharmacopeia type II dissolution apparatus. The results of solid-state studies indicated the presence of strong interactions between meloxicam, moringa, and PVP which were of totally amorphous nature. All ternary combinations were significantly more effective than the corresponding binary systems in improving the dissolution rate of meloxicam. The best performance in this respect was given by the ternary combination employing meloxicam-moringa-PVP ratio of [1:(3:1)] prepared by ball milling, with about six times increase in percent dissolution rate, whereas meloxicam-moringa (1:3) and meloxicam-PVP (1:4) prepared by ball milling improved dissolution of meloxicam by almost 3- and 2.5-folds, respectively. The achieved excellent dissolution enhancement of meloxicam in the ternary systems was attributed to the combined effects of impartation of hydrophilic characteristic by PVP, as well as to the synergistic interaction between moringa and PVP.

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Figures

Fig. 1
Fig. 1
FTIR spectra of fresh ball milled MC, PVP, meloxicam, and SDMMP
Fig. 2
Fig. 2
DSC spectra of fresh ball milled MC, PVP, meloxicam, and SDMMP
Fig. 3
Fig. 3
PXRD spectra of fresh ball milled MC, PVP, meloxicam, and SDMMP
Fig. 4
Fig. 4
DSC spectra of fresh ball milled meloxicam and SDMMP for accelerated stability studies
Fig. 5
Fig. 5
PXRD spectra of fresh ball milled meloxicam and SDMMP for accelerated stability studies
See this image and copyright information in PMC

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