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Editorial
. 2013 May 15;304(10):C941-4.
doi: 10.1152/ajpcell.00072.2013. Epub 2013 Mar 13.

Minding the gaps that link intrinsic circadian clock within the heart to its intrinsic ultradian pacemaker clocks. Focus on "The cardiomyocyte molecular clock, regulation of Scn5a, and arrhythmia susceptibility"

Edward G Lakatta, Yael Yaniv, Victor A Maltsev
Editorial

Minding the gaps that link intrinsic circadian clock within the heart to its intrinsic ultradian pacemaker clocks. Focus on "The cardiomyocyte molecular clock, regulation of Scn5a, and arrhythmia susceptibility"

Edward G Lakatta et al. Am J Physiol Cell Physiol. .
No abstract available

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Figures

Fig. 1.
Fig. 1.
Rhythmic initiation (electrical component) and execution (contractile component) of each heartbeat by a hierarchical clock system (brain-heart) that synchronizes functions of cells within and among other tissues. Impulse is initiated in the sinoatrial node (SAN) and conducted to ventricular myocytes. Bottom: SAN pacemaker cells generate rhythmic electrical impulses that emerge from the SAN. Right panels schematically illustrate that heart-specific disruption of circadian clock (Bmal1-/-) results in abnormal rhythm and rate (ECG) and impulse conduction (QRS).
See this image and copyright information in PMC

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