Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2013 May 15;304(10):C941-4.
doi: 10.1152/ajpcell.00072.2013. Epub 2013 Mar 13.

Minding the gaps that link intrinsic circadian clock within the heart to its intrinsic ultradian pacemaker clocks. Focus on "The cardiomyocyte molecular clock, regulation of Scn5a, and arrhythmia susceptibility"

Edward G Lakatta, Yael Yaniv, Victor A Maltsev
Editorial

Minding the gaps that link intrinsic circadian clock within the heart to its intrinsic ultradian pacemaker clocks. Focus on "The cardiomyocyte molecular clock, regulation of Scn5a, and arrhythmia susceptibility"

Edward G Lakatta et al. Am J Physiol Cell Physiol. .
No abstract available

PubMed Disclaimer

Figures

Fig. 1.
Fig. 1.
Rhythmic initiation (electrical component) and execution (contractile component) of each heartbeat by a hierarchical clock system (brain-heart) that synchronizes functions of cells within and among other tissues. Impulse is initiated in the sinoatrial node (SAN) and conducted to ventricular myocytes. Bottom: SAN pacemaker cells generate rhythmic electrical impulses that emerge from the SAN. Right panels schematically illustrate that heart-specific disruption of circadian clock (Bmal1-/-) results in abnormal rhythm and rate (ECG) and impulse conduction (QRS).
See this image and copyright information in PMC

Comment on

References

    1. Binah O, Weissman A, Itskovitz-Eldor J, Rosen MR. Integrating beat rate variability: from single cells to hearts. Heart Rhythm. doi:10.1016/j.hrthm.2013.02.013 [Epub ahead of print] - DOI - PMC - PubMed
    1. Bray MS, Shaw CA, Moore MW, Garcia RA, Zanquetta MM, Durgan DJ, Jeong WJ, Tsai JY, Bugger H, Zhang D, Rohrwasser A, Rennison JH, Dyck JR, Litwin SE, Hardin PE, Chow CW, Chandler MP, Abel ED, Young ME. Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression. Am J Physiol Heart Circ Physiol 294: H1036–H1047, 2008 - PubMed
    1. Cheng H, Smith GL, Hancox JC, Orchard CH. Inhibition of spontaneous activity of rabbit atrioventricular node cells by KB-R7943 and inhibitors of sarcoplasmic reticulum Ca2+ ATPase. Cell Calcium 49: 56–65, 2011 - PMC - PubMed
    1. Dessauer CW, Posner BA, Gilman AG. Visualizing signal transduction: receptors, G-proteins, and adenylate cyclases. Clin Sci (Lond) 91: 527–537, 1996 - PubMed
    1. Dibner C, Schibler U, Albrecht U. The mammalian circadian timing system: organization and coordination of central and peripheral clocks. Annu Rev Physiol 72: 517–549, 2010 - PubMed

MeSH terms

Substances

LinkOut - more resources