[Possibilities of more accurate evaluation of the degree of myocardial damage and the completeness of reparative processes in patients with acute myocardial infarction by studying the characteristics of monocytes]

Abstract

Patients with acute myocardial infarction (MI) were found to have hyper- and dyslipidemias independent of the depth of myocardial lesions and, in addition, to have more severe granulo- and monocytosis, higher adhesive and phagocytic ability of blood mononuclears that are typical for penetrating MI. Examining biochemical and immunological indices in the time-course of acute MI enables one to assess the completeness of reparative process in the myocardium. A significant and long-term monocyte activation in patients with penetrating MI seems to be due to an extended necrotic area and further formation of a focus aseptic inflammation, from whose the product that stimulate the production and function of blood monocytes are absorbed.