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Review
. 2013 Apr;14(4):197-210.
doi: 10.1038/nrm3546. Epub 2013 Mar 13.

The ATM protein kinase: regulating the cellular response to genotoxic stress, and more

Yosef Shiloh  1 , Yael Ziv
Affiliations
Review

The ATM protein kinase: regulating the cellular response to genotoxic stress, and more

Yosef Shiloh et al. Nat Rev Mol Cell Biol. 2013 Apr.

Abstract

The protein kinase ataxia-telangiectasia mutated (ATM) is best known for its role as an apical activator of the DNA damage response in the face of DNA double-strand breaks (DSBs). Following induction of DSBs, ATM mobilizes one of the most extensive signalling networks that responds to specific stimuli and modifies directly or indirectly a broad range of targets. Although most ATM research has focused on this function, evidence suggests that ATM-mediated phosphorylation has a role in the response to other types of genotoxic stress. Moreover, it has become apparent that ATM is active in other cell signalling pathways involved in maintaining cellular homeostasis.

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