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Comment
. 2013 Apr;133(4):871-4.
doi: 10.1038/jid.2012.426.

CD8 T Cells and IFN-γ emerge as critical players for psoriasis in a novel model of mouse psoriasiform skin inflammation

Paola Di Meglio  1 , João H Duarte
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CD8 T Cells and IFN-γ emerge as critical players for psoriasis in a novel model of mouse psoriasiform skin inflammation

Paola Di Meglio et al. J Invest Dermatol. 2013 Apr.
Free article

Abstract

A pathogenic crosstalk between epithelial and immune cells underpins the aberrant immune and epidermal responses seen in psoriasis. Data from a novel mouse model of psoriasiform skin inflammation not only highlight the importance of the interplay between keratinocytes, targets of genetic manipulation, and T cells as the major effector cells, but also reveal a critical role for CD8 T cells and IFN-γ in disease initiation.

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