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Case Reports
. 2013 Jun;13(3):165-73.
doi: 10.1136/practneurol-2012-000443. Epub 2013 Mar 13.

Rapidly progressive dementia and ataxia in an elderly man

Rebekah M Ahmed  1 , G Michael Halmagyi, Michael L Rodriguez
Affiliations
Free PMC article
Case Reports

Rapidly progressive dementia and ataxia in an elderly man

Rebekah M Ahmed et al. Pract Neurol. 2013 Jun.
Free PMC article
No abstract available

Keywords: Cognition; Dementia; Medicine; Neuropathology.

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Figures

Figure 1
Figure 1
MRI scan of brain at presentation. Axial T2 (A, B) and coronal fluid attenuated inversion recovery sequences show cortical atrophy and ventricular enlargement with possible periventricular cerebrospinal fluid exudation.
Figure 2
Figure 2
EEG shows intermittent generalised 3–4 Hz activity lasting 1 s and continuous generalised 5 Hz activity. The EEG was reactive to eye opening. There are left hemisphere quasiperiodic triphasic waves.
Figure 3
Figure 3
Axial (A, B) and coronal (C) CT 2 weeks after the MRI (figure 1) and 1 week before death showing an increase in the size of the ventricles and in CSF exudation.
Figure 4
Figure 4
Coronal section of cerebrum at the level of the lateral geniculate nuclei showing marked symmetric enlargement of the lateral and third ventricles. The white matter pallor adjacent to the ventricles is due to periventricular oedema secondary to transependymal spread of cerebrospinal fluid.
Figure 5
Figure 5
(A) Moderately well differentiated adenocarcinoma in subarachnoid space (H&E). Original magnification ×100 (B) Adenocarcinoma in subarachnoid space extending into Virchow- Robins space (H&E). Original magnification ×400 (C) Lumbar spinal cord with leptomeningeal carcinomatosis with dorsal and ventral root infiltration. ×12.5 (cytokeratin 8 immunoperoxidase). Original magnification ×12.5. (D) Lumbar ventral roots showing tumour infiltration (cytokeratin 8 immunoperoxidase). Original magnification ×400.
See this image and copyright information in PMC

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