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Case Reports
. 2013 Aug;13(4):278-80.
doi: 10.1136/practneurol-2012-000447. Epub 2013 Mar 13.

Neurological immune-related adverse events of ipilimumab

Ilja Bot  1 , Christian U Blank, Willem Boogerd, Dieta Brandsma
Affiliations
Case Reports

Neurological immune-related adverse events of ipilimumab

Ilja Bot et al. Pract Neurol. 2013 Aug.

Abstract

Ipilimumab enhances the T lymphocyte mediated immune response to both tumour cells and healthy tissue, improving survival in patients with metastatic melanoma but also leads to more immune-related adverse events (irAEs) than previously used treatments, such as dacarbazine. We present three patients with neurological irAEs from ipilimumab treatment: hypophysitis, meningitis and Guillain-Barré syndrome. Once an irAE occurs, ipilimumab should be stopped and corticosteroids started. Usually, ipilimumab-induced irAE symptoms improve within days to weeks, but can be life-threatening if unrecognised.

Keywords: NEUROONCOLOGY; NEUROPHARMACOLOGY.

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