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. 2013 Mar;1278(1):1-10.
doi: 10.1111/nyas.12069.

Biomarkers in nutrition: new frontiers in research and application

Gerald F Combs Jr  1 , Paula R Trumbo, Michelle C McKinley, John Milner, Stephanie Studenski, Takeshi Kimura, Steven M Watkins, Daniel J Raiten
Affiliations
Free PMC article

Biomarkers in nutrition: new frontiers in research and application

Gerald F Combs Jr et al. Ann N Y Acad Sci. 2013 Mar.
Free PMC article

Abstract

Nutritional biomarkers--biochemical, functional, or clinical indices of nutrient intake, status, or functional effects--are needed to support evidence-based clinical guidance and effective health programs and policies related to food, nutrition, and health. Such indices can reveal information about biological or physiological responses to dietary behavior or pathogenic processes, and can be used to monitor responses to therapeutic interventions and to provide information on interindividual differences in response to diet and nutrition. Many nutritional biomarkers are available; yet there has been no formal mechanism to establish consensus regarding the optimal biomarkers for particular nutrients and applications.

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Figures

Figure 1
Figure 1
The Biomarkers of Nutrition and Development (BOND) program.
Figure 2
Figure 2
Risk reduction relationships implied by FDA-approved health claims.
Figure 3
Figure 3
Types of biomarkers available for assessing Se intake, status, and function.
Figure 4
Figure 4
Candidate biomarkers of sarcopenia.
Figure 5
Figure 5
Need for biomarkers of host susceptibility in assessing the health impacts of bioactive substances.
Figure 6
Figure 6
Opportunities to use disruptions in normal correlations among circulating free amino acids as biomarkers of health conditions, for example, effects of changes in dietary protein intake in the rat.
See this image and copyright information in PMC

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