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Multicenter Study
. 2013 Aug 1;63(4):438-41.
doi: 10.1097/QAI.0b013e31828e6163.

Plasma viremia and cellular HIV-1 DNA persist despite autologous hematopoietic stem cell transplantation for HIV-related lymphoma

Anthony R Cillo  1 , Amrita Krishnan, Ronald T Mitsuyasu, Deborah K McMahon, Shirley Li, John J Rossi, John A Zaia, John W Mellors
Affiliations
Multicenter Study

Plasma viremia and cellular HIV-1 DNA persist despite autologous hematopoietic stem cell transplantation for HIV-related lymphoma

Anthony R Cillo et al. J Acquir Immune Defic Syndr. .

Abstract

A cure of HIV-1 has been achieved in one individual through allogeneic stem cell transplantation with a CCR5[INCREMENT]32 homozygous donor. Whether myeloablation and autologous stem cell transplantation for lymphoma in patients on suppressive antiretroviral therapy can eliminate HIV-1 reservoirs is unknown. Low-level plasma viremia and total HIV-1 DNA and 2-LTR circles in blood mononuclear cells were quantified after autologous transplantation in 10 patients on suppressive antiretroviral therapy using quantitative polymerase chain reaction assays capable of single-copy nucleic acid detection. Plasma viremia was detectable in 9 patients, whereas HIV-1 DNA was detectable in all 10 patients, indicating that HIV-1 had not been eliminated.

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Conflict of interest statement

Conflicts of Interest: J.W.M. is a consultant for Gilead Sciences and RFS Pharma and owns shares of RFS Pharma. A.R.C., A.K., R.T.M., D.K.M., S.L., J.J.R., and J.A.Z. have no conflicts of interest relevant to this article.

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