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Editorial
. 2013 Mar 15;112(6):876-7.
doi: 10.1161/CIRCRESAHA.113.300947.

Yin-Yang 1, a new player in early heart development

Yuka Morikawa, John Leach, James F Martin
Editorial

Yin-Yang 1, a new player in early heart development

Yuka Morikawa et al. Circ Res. .
No abstract available

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Figures

Fig.1
Fig.1. Conceptual model of YY1 and GATA4 transcriptional activation of Nkx2-5
The YY1 and GATA4 binding domain has been mapped to a 2.1kb region upstream of the Nkx2-5 promotor. Additionally, TBX5 and SRF binding motifs are located near the YY1 and GATA4 binding domain. PRMT1 and p300 are known transcription co-activators of YY1. Other potential targets of YY1 transcriptional activation include Pitx2, Tbx3, Tbx5, Mef2c.
See this image and copyright information in PMC

Comment on

References

    1. Gregoire S, Karra R, Passer D, Deutsch MA, Krane M, Feistritzer R, Sturzu A, Domian I, Saga Y, Wu SM. Essential and unexpected role of yy1 to promote mesodermal cardiac differentiation. Circ Res. 2013;112:xxx–xxx. in this issue. - PMC - PubMed
    1. Noseda M, Peterkin T, Simoes FC, Patient R, Schneider MD. Cardiopoietic factors: Extracellular signals for cardiac lineage commitment. Circulation research. 2011;108:129–152. - PubMed
    1. Thomas MJ, Seto E. Unlocking the mechanisms of transcription factor yy1: Are chromatin modifying enzymes the key? Gene. 1999;236:197–208. - PubMed
    1. Sucharov CC, Dockstader K, McKinsey TA. Yy1 protects cardiac myocytes from pathologic hypertrophy by interacting with hdac5. Molecular biology of the cell. 2008;19:4141–4153. - PMC - PubMed
    1. Caretti G, Di Padova M, Micales B, Lyons GE, Sartorelli V. The polycomb ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation. Genes & development. 2004;18:2627–2638. - PMC - PubMed

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