Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Oct;16(4):492-7.
doi: 10.4103/0972-124X.106880.

Effects of hyperbaric oxygen on aggressive periodontitis and subgingival anaerobes in Chinese patients

Tie-Lou Chen  1 , Bing Xu, Jing-Chang Liu, Shu-Guang Li, De-Yi Li, Guo-Chuan Gong, Zhi-Fen Wu, Shi-Long Lin, Yi-Jun Zhou
Affiliations

Effects of hyperbaric oxygen on aggressive periodontitis and subgingival anaerobes in Chinese patients

Tie-Lou Chen et al. J Indian Soc Periodontol. 2012 Oct.

Abstract

Objective: To investigate the effects of hyperbaric oxygen (HBO2) on aggressive periodontitis (AgP), and subgingival obligate anaerobes in Chinese patients.

Materials and methods: Sixty cases of Chinese patients with AgP were randomly divided into two groups -the HBO2 group (30 cases) and the control group (30 cases). Study teeth were divided into four groups -: the HBO2 therapy, the HBO2 + scaling scaling group, the scaling group and the control group. Subgingival anaerobic organisms were measured with anaerobic culture, and number of obligate anaerobes and facultative anaerobes and Bacteroides melaninogenicus was counted. Comparisons of changes in the clinical indices, and subgingival anaerobes were made between the groups.

Results: Highly significant differences in gingival index (GI), probing depth (PD), attachment loss (AL), and Plaque index (PLI), and tooth odontoseisis (TO) were seen in the HBO2, the HBO2 + scaling and the scaling groups when compared with the control group (P<0.01). The number of subgingival anaerobes as well as the types of obligate anaerobes and facultative anaerobes and the number of Bacteroides melaninogenicus were reduced markedly in these three treatment groups. Highly statistical differences in clinical indices, subgingival anaerobe number and types of obligate anaerobes and facultative anaerobes and Bacteroides melaninogenicus were found when comparisons were made between the HBO2 + scaling and the HBO2 groups, as well as between the HBO2 + scaling and the scaling groups. Clinical follow-ups indicated that the GI, PD, AL, TO, PLI and subgingival anaerobes number of the three therapeutic groups were reduced more severely than the control group.

Conclusions: HBO2 had good therapeutic effects on Chinese patients with AgP. HBO2 therapy combined with scaling and root planing was the most beneficial in the treatment of AgP. The therapeutic effect of HBO2 on AgP is most likely through inhibition of the growth of subgingival anaerobes. Clinical follow-ups suggest that the effect could last more than 2 years.

Keywords: Aggressive periodontitis; Chinese; hyperbaric oxygen; subgingival anaerobes.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: None declared.

References

    1. Lopez NJ. Occurrence of actinobacillus actinomycetemcomitans. Porphyromonas gingivalis, prevotella intermedia, in progressive adult periodontitis. J Periodontol. 2000;71:948–54. - PubMed
    1. Lopez NJ, Socransky SS, Da Silva I. Subgingival microbiota of Chilean patients with chronic periodontitis. J Periodontol. 2004;75:717–25. - PubMed
    1. Lopez NJ, Jara L, Valenzuela CY. Association of interleukin-1 polymorphisms with periodontal disease. J Periodontol. 2005;76:234–43. - PubMed
    1. Chen TL, Zhou YJ, Liu JC, Xu B, Wu ZF. Biological effects of hyperbaric oxygen on severe human periodontitis. Undersea Hyperb Med. 2002;29:159–66. - PubMed
    1. Chen TL, Liu JC, Xu B, Lin SL. Effects of hyperbaric oxygen on periodontitis and subgingival anaerobes. West China J Stomatol. 1998;16:332–4. - PMC - PubMed

LinkOut - more resources