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. 2008 Jul;2(7):801-11.
doi: 10.1517/17530059.2.7.801.

Biomarkers for malignant peripheral nerve sheath tumours

D E Reuss  1 , A von Deimling
Affiliations

Biomarkers for malignant peripheral nerve sheath tumours

D E Reuss et al. Expert Opin Med Diagn. 2008 Jul.

Abstract

Background: Malignant peripheral nerve sheath tumour (MPNST) is a highly aggressive soft tissue sarcoma affecting predominantly patients with neurofibromatosis type I. The appearance of MPNST varies considerably and discrimination from other high-grade soft tissue tumours as well as cellular variants of benign nerve sheath tumours may be difficult. Therefore, there is great interest in defining biological markers for MPNST.

Objective: This review summarises research on the pathogenesis and progress in diagnostics of MPNST.

Methods: The literature on MPNST focusing on pathogenesis and potential biomarkers was reviewed.

Conclusion: Recent molecular analyses contributed significantly to our understanding of MPNST. Candidate markers and expression signatures await further validation for their feasibility in guiding diagnostic and therapeutic decisions.

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