Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Mar 13;5(1):15.
doi: 10.1186/1758-5996-5-15.

Low serum adiponectin concentrations are associated with insulin sensitivity independent of obesity in Sudanese subjects with type 2 diabetes mellitus

Moawia Abdelgadir  1 , Anders F Karlsson, Lars Berglund, Christian Berne
Affiliations

Low serum adiponectin concentrations are associated with insulin sensitivity independent of obesity in Sudanese subjects with type 2 diabetes mellitus

Moawia Abdelgadir et al. Diabetol Metab Syndr. .

Abstract

Aims: Prevalence of Type 2 diabetes mellitus among Sudanese population was found to be 3.4% and associated with high rates of complications and obesity. Different adipocytokines are secreted from adipose tissues, among them adiponectin, which was shown to have insulins ensitizing properties and anti-inflammatory, anti-atherogenic effect. The aim of this study was to characterize type 2 diabetes in Sudanese diabetic subjects and controls in respect to hormones influencing or influenced by glucose metabolism.

Methods: 104 type 2 diabetic patients (45 men and 59 women), and 75 matched control subjects (34 men and 41 women) were studied. Fasting serum samples were used to measure adiponectin, leptin, insulin, proinsulin, ghrelin and glucose. Body mass index, insulin/proinsulin ratio and (HOMA) insulin resistance and beta cell function were also calculated.

Results: Adiponectin serum concentrations were significantly lower in subjects with type 2 diabetes compared with controls subjects (P = 0.002), comparison between males and females did not reach significant levels in both diabetic (P = 0.06) or controls (P = 0.16) groups. In the diabetic group adiponectin correlated positively with serum glucose, negatively with serum proinsulin and HOMA beta cell function (P = 0.03) respectively and serum ghrelin (P = 0.003), but not with BMI, HOMA insulin resistance, insulin or leptin. In controls serum adiponectin correlated negatively with BMI (P = 0.002) but not with other variables.

Conclusions: The findings of this study suggest that, adiponectin concentrations independent on BMI as a measure of adiposity, were mostly linked to insulin sensitivity and not to insulin resistance in Sudanese type 2 diabetic subjects, where race specific regulation mechanisms or different type 2 diabetes phenotype suggested being a major contributory factor in clarification the findings of this study.

PubMed Disclaimer

References

    1. Reaven GM. Role of insulin resistance in human disease. Diabetes. 1988;37:1595–1607. doi: 10.2337/diabetes.37.12.1595. - DOI - PubMed
    1. Mantozoros C, Flier J. Insulin resistance: the clinical spectrum. Adv Endocrinol Metab. 1995;19:193–232. - PubMed
    1. Lillioja S, Mott D, Spraul M, Ferraro R, Foley JE, Ravussin E, Knowler WC, Bennett PH, Bogardus C. Insulin resistance and insulin secretory dysfunction as precursors for noninsulin dependant diabetes mellitus. N Eng J Med. 1993;329:1988–1992. doi: 10.1056/NEJM199312303292703. - DOI - PubMed
    1. Elbagir M, Eltom M, Elmehadi M, Kadam IM, Berne C. Population-based study of the prevalence of diabetes mellitus and impaired glucose tolerance in adults among in Northern Sudan. Diabetes Care. 1996;19:1126–1128. doi: 10.2337/diacare.19.10.1126. - DOI - PubMed
    1. Elmehadi M, Abdel Rahman L, Mukhtar S. Patterns of diabetes mellitus in Sudan. Trop Geog Med. 1989;4:353–355. - PubMed

LinkOut - more resources