Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Mar 15:6:98.
doi: 10.1186/1756-0500-6-98.

Emerging threat of multidrug resistant bugs--Acinetobacter calcoaceticus baumannii complex and methicillin resistant Staphylococcus aureus

Shyam Kumar Mishra  1 , Basista Prasad Rijal, Bharat Mani Pokhrel
Affiliations

Emerging threat of multidrug resistant bugs--Acinetobacter calcoaceticus baumannii complex and methicillin resistant Staphylococcus aureus

Shyam Kumar Mishra et al. BMC Res Notes. .

Abstract

Background: Infections caused by bacteria such as multidrug resistant (MDR) Acinetobacter spp. and methicillin-resistant Staphylococcus aureus (MRSA) constitute a worldwide pandemic. Without gathering information about these strains, we cannot reduce the morbidity and mortality due to infections caused by these notorious bugs.

Methods: This study was conducted to identify the status of MDR Acinetobacter spp. and MRSA in a tertiary care centre of Nepal. Sputum, endotracheal aspirate and bronchial washing specimens were collected and processed from patients suspected of lower respiratory tract infection following standard microbiological methods recommended by the American Society for Microbiology (ASM). Double disk synergy test method was employed for the detection of extended-spectrum beta-lactamase (ESBL) in Acinetobacter isolates. Methicillin resistance in S. aureus was confirmed by using cefoxitin and oxacillin disks.

Results: Different genomespecies of Acinetobacter were isolated; these consisted of Acinetobacter calcoaceticus baumannii complex and A. lwoffii. Around 95% of Acinetobacter isolates were MDR, while 12.9% were ESBL-producer. Of the total 33 isolates of S. aureus, 26 (78.8%) were MDR and 14 (42.4%) were methicillin resistant.

Conclusions: A large number of MDR Acinetobacter spp. and MRSA has been noted in this study. The condition is worsened by the emergence of ESBL producing Acinetobacter spp. Hence, judicious use of antimicrobials is mandatory in clinical settings. Moreover, there should be vigilant surveillance of resistant clones in laboratories.

PubMed Disclaimer

References

    1. Bergogne-Berezin E, Towner KJ. Acinetobacter species as nosocomial pathogens: microbiological, clinical, and epidemiological features. Clin Micro Rev. 1999;9:148–165. - PMC - PubMed
    1. Cohen J, Powderly WG. Infectious disease. 2. Vol. 1. Mosby: Elsevier; 2004. Community-acquired pneumonia; pp. 369–380.
    1. Mammina C, Calà C, Bonura C, Carlo PD, Aleo A, Fasciana T, Giammanco A. EPI-MRSA Working Group. Polyclonal non multiresistant Staphylococcus aureus isolates from clinical cases of infection occurring in Palermo, Italy, during a one-year surveillance period. Ann Clin Microbiol Antimicrob. 2012;11:17. doi: 10.1186/1476-0711-11-17. - DOI - PMC - PubMed
    1. Lesosky M, McGeer A, Simor A, Green K, Low DE, Raboud J. Effect of patterns of transferring patients among healthcare institutions on rates of nosocomial methicillin-resistant Staphylococcus aureus transmission: a Monte Carlo simulation. Infect Contr Hosp Epidemiol. 2011;32:136–147. doi: 10.1086/657945. - DOI - PubMed
    1. HD I. Clinical Microbiology Procedures Handbook. 2. Washington DC: ASM press; 2004.

Publication types

MeSH terms

Substances