Comment on

• Effect of long-term exposure to lower low-density lipoprotein cholesterol beginning early in life on the risk of coronary heart disease: a Mendelian randomization analysis.

  Ference BA, Yoo W, Alesh I, Mahajan N, Mirowska KK, Mewada A, Kahn J, Afonso L, Williams KA Sr, Flack JM. Ference BA, et al. J Am Coll Cardiol. 2012 Dec 25;60(25):2631-9. doi: 10.1016/j.jacc.2012.09.017. Epub 2012 Oct 17. J Am Coll Cardiol. 2012. PMID: 23083789 Review.
• Mendelian randomization estimates may be inflated.

  Schooling CM, Au Yeung SL, Freeman G. Schooling CM, et al. J Am Coll Cardiol. 2013 May 7;61(18):1931. doi: 10.1016/j.jacc.2012.12.049. Epub 2013 Mar 7. J Am Coll Cardiol. 2013. PMID: 23500241 No abstract available.