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Comment
. 2013 Mar-Apr;7(2):71-3.
doi: 10.4161/chan.24163. Epub 2013 Mar 1.

CRACking the structure of Orai: new work reveals the intramolecular properties of a store-operated, calcium influx channel

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Comment

CRACking the structure of Orai: new work reveals the intramolecular properties of a store-operated, calcium influx channel

Andrew P Braun. Channels (Austin). 2013 Mar-Apr.
No abstract available

Keywords: CRAC channel; X-ray crystallography; pore structure; selectivity filter; stoichiometry.

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References

    1. Roos J, DiGregorio PJ, Yeromin AV, Ohlsen K, Lioudyno M, Zhang S, et al. STIM1, an essential and conserved component of store-operated Ca2+ channel function. J Cell Biol. 2005;169:435–45. doi: 10.1083/jcb.200502019. - DOI - PMC - PubMed
    1. Feske S, Gwack Y, Prakriya M, Srikanth S, Puppel SH, Tanasa B, et al. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature. 2006;441:179–85. doi: 10.1038/nature04702. - DOI - PubMed
    1. Penna A, Demuro A, Yeromin AV, Zhang SL, Safrina O, Parker I, et al. The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers. Nature. 2008;456:116–20. doi: 10.1038/nature07338. - DOI - PMC - PubMed
    1. Mignen O, Thompson JL, Shuttleworth TJ. Orai1 subunit stoichiometry of the mammalian CRAC channel pore. J Physiol. 2008;586:419–25. doi: 10.1113/jphysiol.2007.147249. - DOI - PMC - PubMed
    1. Demuro A, Penna A, Safrina O, Yeromin AV, Amcheslavsky A, Cahalan MD, et al. Subunit stoichiometry of human Orai1 and Orai3 channels in closed and open states. Proc Natl Acad Sci U S A. 2011;108:17832–7. doi: 10.1073/pnas.1114814108. - DOI - PMC - PubMed

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