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Comparative Study
. 1990 May;29(5):574-7.
doi: 10.1111/j.1365-2125.1990.tb03682.x.

A comparative pharmacokinetic study of conventional and chewable carbamazepine in epileptic patients

P N Patsalos  1
Affiliations
Comparative Study

A comparative pharmacokinetic study of conventional and chewable carbamazepine in epileptic patients

P N Patsalos. Br J Clin Pharmacol. 1990 May.

Abstract

Using an open substitution study design, conventional carbamazepine (Tegretol, CBZ-C and a chewable carbamazepine formulation (Tegretol Chewtabs, CBZ-CHEW) were compared in 12 patients with severe intractable epilepsy. During a dosing interval, no significant differences were observed with respect to trough or peak serum concentrations of CBZ and CBZ-10,11-epoxide (CBZ-E), the active metabolite. The area under the serum CBZ concentration-time curve for a dosing interval was (mean +/- s.e. mean) 146 +/- 10 mumols l-1 h on CBZ-C and 143 +/- 9 mumols l-1 h on CBZ-CHEW. The two formulations, therefore, have a similar pharmacokinetic profile and could be used interchangeably in the management of patients with epilepsy.

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