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. 2013 Apr 16;47(8):3902-8.
doi: 10.1021/es3046839. Epub 2013 Apr 1.

Hydroxylated polybrominated diphenyl ethers in paired maternal and cord sera

Aimin Chen  1 , June-Soo Park, Linda Linderholm, Alexandra Rhee, Myrto Petreas, Emily A DeFranco, Kim N Dietrich, Shuk-Mei Ho
Affiliations

Hydroxylated polybrominated diphenyl ethers in paired maternal and cord sera

Aimin Chen et al. Environ Sci Technol. .

Abstract

Polybrominated diphenyl ethers (PBDEs) were widely used as flame retardants in the past three decades. These compounds are lipophilic and easily cross the placenta from pregnant woman to fetus. It is not clear whether hydroxylated PBDEs (OH-PBDEs), with greater hydrophilicity, have different concentrations in maternal and cord serum samples. We analyzed PBDEs (BDE-28, -47, -99, -100, -153, -154, -209) and OH-PBDEs (6-OH-BDE-47, 5-OH-BDE-47, 4'-OH-BDE-49, 5'-OH-BDE-99) in 20 pairs of maternal and cord serum samples collected in Cincinnati, OH in 2011. The geometric mean concentration of ∑OH-BDEs (the sum of four OH-PBDEs) was 49.76 pg/mL in cord sera, higher than 32.84 pg/mL in maternal sera. Similarly, cord serum total BDEs had a higher geometric mean than maternal serum (45.51 vs 32.07 ng/g lipid). Equal or higher levels of total OH-BDEs and total BDEs in cord serum were observed in 85% and 80% of the mother-neonate pairs, respectively. The study suggests fetuses might receive higher OH-PBDE and PBDE exposure than their mothers.

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Figures

Figure 1
Figure 1
Total BDEs in paired maternal and cord serum samples in Cincinnati, OH 2011 (n=20, ng/g lipid)
Figure 2
Figure 2
Total OH-BDEs in paired maternal and cord serum samples in Cincinnati, OH 2011 (n=20, pg/ml)
Figure 3
Figure 3
Scatter plot and simple regression line of birth weight by concentrations of total BDEs and total OH-BDEs in maternal and cord serum samples, with x-axis on natural log scale. A: Birth weight by maternal total BDEs; B: Birth weight by maternal total OH-BDEs; C: Birth weight by cord total BDEs; D: Birth weight by cord total OH-BDEs.
See this image and copyright information in PMC

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