Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2013 Apr-Jun;34(2-3):516-28.
doi: 10.1016/j.mam.2012.07.010.

SLC27 fatty acid transport proteins

Courtney M Anderson  1 , Andreas Stahl
Affiliations
Review

SLC27 fatty acid transport proteins

Courtney M Anderson et al. Mol Aspects Med. 2013 Apr-Jun.

Abstract

The uptake and metabolism of long chain fatty acids (LCFA) are critical to many physiological and cellular processes. Aberrant accumulation or depletion of LCFA underlie the pathology of numerous metabolic diseases. Protein-mediated transport of LCFA has been proposed as the major mode of LCFA uptake and activation. Several proteins have been identified to be involved in LCFA uptake. This review focuses on the SLC27 family of fatty acid transport proteins, also known as FATPs, with an emphasis on the gain- and loss-of-function animal models that elucidate the functions of FATPs in vivo and how these transport proteins play a role in physiological and pathological situations.

PubMed Disclaimer

Figures

Figure 1
Figure 1. Protein structure of FATP1
Structural domains of FATP1 are listed on the right. Locations of the domains within FATP1 are indicated by amino acid residue number. *ER localization domain has been identified only in FATP4.
Figure 2
Figure 2. FATP expression pattern in vivo
Relative expression levels of FATPs in mammalian tissues. Increasing font size corresponds to greater expression levels. *FATP5 is expressed only in the liver and FATP6 is expressed almost exclusively in the heart. #Relative expression level of each FATP in endothelial cells has not been determined.
See this image and copyright information in PMC

References

    1. Amri EZ, Bonino F, Ailhaud G, Abumrad NA, Grimaldi PA. Cloning of a protein that mediates transcriptional effects of fatty acids in preadipocytes. Homology to peroxisome proliferator-activated receptors. J Biol Chem. 1995;270(5):2367–2371. - PubMed
    1. Ason B, Castro-Perez J, Tep S, Stefanni A, Tadin-Strapps M, Roddy T, Hankemeier T, Hubbard B, Sachs AB, Michael Flanagan W, Kuklin NA, Mitnaul LJ. ApoB siRNA-induced liver steatosis is resistant to clearance by the loss of fatty acid transport protein 5 (Fatp5) Lipids. 2011;46(11):991–1003. - PMC - PubMed
    1. Auinger A, Helwig U, Pfeuffer M, Rubin D, Luedde M, Rausche T, Eddine El Mokhtari N, Folsch UR, Schreiber S, Frey N, Schrezenmeir J. A variant in the heart-specific fatty acid transport protein 6 is associated with lower fasting and postprandial TAG, blood pressure and left ventricular hypertrophy. Br J Nutr. 2011:1–7. - PubMed
    1. Auinger A, Valenti L, Pfeuffer M, Helwig U, Herrmann J, Fracanzani AL, Dongiovanni P, Fargion S, Schrezenmeir J, Rubin D. A promoter polymorphism in the liver-specific fatty acid transport protein 5 is associated with features of the metabolic syndrome and steatosis. Horm Metab Res. 2010;42(12):854–859. - PubMed
    1. Binnert C, Koistinen HA, Martin G, Andreelli F, Ebeling P, Koivisto VA, Laville M, Auwerx J, Vidal H. Fatty acid transport protein-1 mRNA expression in skeletal muscle and in adipose tissue in humans. Am J Physiol Endocrinol Metab. 2000;279(5):E1072–1079. - PubMed

Publication types