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Review
. 2013 Apr;59(4):119-38.
doi: 10.1016/j.disamonth.2013.01.003.

Chemical exposure and hearing loss

Pierre Campo, Thais C Morata, OiSaeng Hong
Review

Chemical exposure and hearing loss

Pierre Campo et al. Dis Mon. 2013 Apr.
No abstract available

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Cross section of the cochlea. mb, membrane. Left bottom panel: organ of Corti. (Color version of the figure is available online.)
Fig. 2
Fig. 2
Mechanisms of aminoglycoside-induced outer hair cell damage. AG, aminoglycoside; AG–Fe, aminoglycoside– iron complex; ROS, reactive oxygen species; JNK, c-Jun N-terminal kinase; Cyt C, cytochrome C. Adapted from Rybak and Ramkumar.
Fig. 3
Fig. 3
Mechanisms of anticancer drug toxicity. CP, cisplatin; MHC, monohydrate complex; ROS, reactive oxygen species; NOX-3, NADPH oxidase 3; Cyt C, cytochrome C. Adapted from Rybak and Ramkumar.
Fig. 4
Fig. 4
Intoxication route for different medicines and work-related substances. (A) Anti-neoplastic drugs and aminoglycosides are hydrophilic substances, whereas solvents are lipophilic substances. (B) Loop diuretics modify the activity of the ionic pumps, whereas aspirin affects blood fluidity within the stria vascularis. As a result, the ionic concentration of endolymph is disturbed until the molecules are cleared from the system. (Color version of the figure is available online.)
Fig. 5
Fig. 5
Scanning electron micrograph of a rat organ of Corti prior to- (A) and post- (B) toluene exposure. When present, the stereocilia of the hair cells look normal in both images.
Fig. 6
Fig. 6
Neural presbycusis. Mid-modular cut cochlea. The left panels correspond to a 25-month-old rat, whereas the right panels correspond to a 5-month-old rat. (Color version of the figure is available online.)
See this image and copyright information in PMC

References

    1. Parent-Thirion A, Fernández Macías E, Hurley J, Vermeylen G. Fourth European Working Conditions Survey, European Foundation for the Improvement of Living and Working Conditions. Dublin: 2007.
    1. Bergström B, Nyström B. Development of hearing loss during long-term exposure to occupational noise—a 20-year follow-up study. Scand Audiol. 1986;15:227–234. - PubMed
    1. Daniell W, Swan S, McDaniel M, Camp J, Cohen M, Stebbins J. Noise exposure and hearing loss prevention programmes after 20 years of regulations in the US. Occup Environ Med. 2006;63:343–351. - PMC - PubMed
    1. Morata T. Chemical exposure as a risk factor for hearing loss. J Occup Environ Med. 2003;45:676–682. - PubMed
    1. EU-OSHA European Agency for Safety and Health at Work. Combined exposure to noise and ototoxic substances. 2009:3–60.

MeSH terms