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. 2013 May;146(1-3):336-43.
doi: 10.1016/j.schres.2013.02.028. Epub 2013 Mar 16.

Disruption of function-structure coupling in brain regions sub-serving self monitoring in schizophrenia

Tsuyoshi Araki  1 , Margaret Niznikiewicz, Toshiro Kawashima, Paul G Nestor, Martha E Shenton, Robert W McCarley
Affiliations

Disruption of function-structure coupling in brain regions sub-serving self monitoring in schizophrenia

Tsuyoshi Araki et al. Schizophr Res. 2013 May.

Abstract

Deficits in self monitoring are a core feature of cognitive dysfunction in schizophrenia, and may be the basis for disturbances of self and lack of insight, ultimately impacting social functioning. However, the functional and structural neural correlates of such deficits in self monitoring are not well understood. We investigated this issue using measurements of neurophysiological and structural brain indices, i.e., error-related and correct-response negativity (ERN & CRN) of event-related potentials, and gray matter volume of the anterior cingulate cortex (ACC), and tested whether the association between these indices is altered in patients with schizophrenia. Participants consisted of 18 male patients with chronic schizophrenia and 18 healthy male controls. The 2 groups did not differ in ERN amplitude. In contrast, schizophrenia patients showed significantly larger CRN amplitudes than did healthy subjects. Although the 2 groups did not significantly differ in gray matter volume of the ACC subregions, a significant negative correlation was found between ERN amplitudes at the frontocentral electrodes and absolute gray matter volumes of the left cognitive region of ACC only in healthy controls. These results suggest a disruption of function-structure coupling of the brain regions sub-serving self monitoring in schizophrenia.

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Conflict of interest statement

Conflict of Interest

All authors declared no conflict of interest including any financial, personal or other relationships with other people or organizations within 3 years of beginning the work submitted that could inappropriately influence, or be perceived to influence, their work.

Figures

Figure 1
Figure 1
Response-locked grand average event related potential (ERP) waveforms from healthy subjects following errors (thick lines) and correct responses (dotted lines).
Figure 2
Figure 2
Response-locked grand average event related potential (ERP) waveforms from patients with schizophrenia following errors (thick lines) and correct responses (dotted lines).
Figure 3
Figure 3
Response-locked grand average event related potential (ERP) waveforms from healthy subjects (thick lines) and patients with schizophrenia (dotted lines) following errors.
Figure 4
Figure 4
Response-locked grand average event related potential (ERP) waveforms from healthy subjects (thick lines) and patients with schizophrenia (dotted lines) following correct responses.
Figure 5
Figure 5
The scatterplot shows the relationship between ERN amplitude and the absolute gray matter volume of the left cognitive subregion of anterior cingulate gyrus.
See this image and copyright information in PMC

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