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Review
. 2012 Jan-Mar;2(1):1-14.
doi: 10.4161/biom.19429.

Regenerative therapy and tissue engineering for the treatment of end-stage cardiac failure: new developments and challenges

G T Finosh  1 , Muthu Jayabalan
Affiliations
Review

Regenerative therapy and tissue engineering for the treatment of end-stage cardiac failure: new developments and challenges

G T Finosh et al. Biomatter. 2012 Jan-Mar.

Abstract

Regeneration of myocardium through regenerative therapy and tissue engineering is appearing as a prospective treatment modality for patients with end-stage heart failure. Focusing on this area, this review highlights the new developments and challenges in the regeneration of myocardial tissue. The role of various cell sources, calcium ion and cytokine on the functional performance of regenerative therapy is discussed. The evolution of tissue engineering and the role of tissue matrix/scaffold, cell adhesion and vascularisation on tissue engineering of cardiac tissue implant are also discussed.

Keywords: end-stage cardiac failure; new developments and challenges; regenerative therapy; tissue engineering.

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Figures

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Figure 1. Influence of calcium on the functioning of cardiomyocyte.
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Figure 2. Nature and role of various growth factors in regenerative therapy.
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Figure 3. The general procedure for cardiac tissue engineering.
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Figure 4. Essential characteristics of an ideal tissue engineering scaffold.
See this image and copyright information in PMC

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