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. 2014 Mar;19(3):279-81.
doi: 10.1038/mp.2013.29. Epub 2013 Mar 19.

Amphetamine-induced behavior requires CaMKII-dependent dopamine transporter phosphorylation

A B Pizzo  1 , C S Karam  1 , Y Zhang  1 , C L Ma  2 , B D McCabe  3 , J A Javitch  4
Affiliations

Amphetamine-induced behavior requires CaMKII-dependent dopamine transporter phosphorylation

A B Pizzo et al. Mol Psychiatry. 2014 Mar.
No abstract available

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Conflict of interest statement

CONFLICT OF INTEREST

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
(a) Control larvae carrying non-driven UAS-CaMKIINtide responded to amphetamine (AMPH) by significantly increasing their crawling speed. CaMKIINtide driven by TH-GAL4 blunted the locomotor response. (b) Control larvae with either non-driven CaMKIINtide or CaMKIINtide driven by TH-GAL4 responded to methylphenidate (MPH) by significantly increasing their locomotor speed. (c–e) Experiments were performed in a dDATfmn null mutant background. (c) CaMKIINtide driven by TH-GAL4 inhibited the AMPH response mediated by human DAT (hDAT). (d) CaMKIINtide driven by TH-GAL4 did not inhibit the MPH response mediated by hDAT. (e) Expression of mutant hDAT-S/D rescued the response to AMPH that was blunted by CaMKIINtide. In all panels, UAS-CaMKIINtide indicates larvae carrying 2 copies of the transgene. Boxplots represent the median as the middle line, with the lower and upper edges of the boxes representing the 25% and 75% quartiles, respectively, and the whiskers representing the 5% and 95% quantiles. Asterisks indicate the statistical significance of the difference in mean velocity of larvae-fed drug as compared to larvae of the same genotype-fed vehicle, as determined using the nonparametric Mann–Whitney–Wilcoxon test using GraphPad Prism (NS P>0.05, ***P<0.001).
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