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Review
. 2013 Dec;149(3):279-85.
doi: 10.1016/j.clim.2013.02.003. Epub 2013 Feb 14.

Anti-cytokine therapies in T1D: Concepts and strategies

Gerald T Nepom  1 , Mario Ehlers, Thomas Mandrup-Poulsen
Affiliations
Review

Anti-cytokine therapies in T1D: Concepts and strategies

Gerald T Nepom et al. Clin Immunol. 2013 Dec.

Abstract

Therapeutic targeting of proinflammatory cytokines is clinically beneficial in several autoimmune disorders. Several of these cytokines are directly implicated in the pathogenesis of type 1 diabetes, suggesting opportunities for design of clinical trials in type 1 diabetes that incorporate selective cytokine blockade as a component of preventative or interventional immunotherapy. The rationale and status of inhibitory therapy directed against IL-1, TNF, IL-12, IL-23, and IL-6 are discussed, towards a goal of using cytokine inhibition as a therapeutic platform to establish an in vivo milieu suitable for modulating the immune response in T1D.

Keywords: Anti-inflammatory; Autoimmunity; DAMPs; IL-1 receptor accessory protein; IL-1 receptor antagonist; IL-1RA; IL-1RAcP; Immunotherapy; LPS; NOD; ROS; Regulatory T cells; T1D; T2D; TLR; TXNIP; Teff; Treg; damage/danger-associated molecular patterns; effector T cell(s); lipopolysaccharide; non-obese diabetic (mice); reactive oxygen species; regulatory T cell(s); thioredoxin inhibitory protein; toll-like receptor; type 1 diabetes; type 2 diabetes.

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