Electrosprayed nanoparticles for drug delivery and pharmaceutical applications

Abstract

Nanotechnology based Pharma has emerged significantly and has influenced the Pharma industry up to a considerable extent. Nanoparticles technology holds a good share of the nanotech Pharma and is significant in comparison with the other domains. Electrospraying technology answers the potential needs of nanoparticle production such as scalability, reproducibility, effective encapsulation etc. Many drugs have been electrosprayed with and without polymer carriers. Drug release characteristics are improved with the incorporation of biodegradable polymer carriers which sustain the release of encapsulated drug. Electrospraying is acknowledged as an important technique for the preparation of nanoparticles with respect to pharmaceutical applications. Herein we attempted to consolidate the reports pertaining to electrospraying and their corresponding therapeutic application area.

Keywords: drug delivery; electrospray; nanomedicine; nanoparticle; sustained release.

Figure 1. Projected timelines for Nanopharma “from research to market”.

Figure 2. Existing Nanomedicine in clinical usage.

Figure 3. Illustration for electro spraying technique.

Figure 4. Antimicrobial efficacy and bactericidal efficiency as a measure of silver/silica nanoparticle sample concentration.

Figure 5. SEM image of the composite lactose plus BSA obtained by EHDA and SDS-PAGE of the BSA not processed and of 4 different samples of the composite lactose–BSA. Lanes 1, 2 and 4, lactose exposed to the jet for 1200s. Lane 3, lactose exposed to the jet for 3600s.

Figure 6. Monodisperse wax emulsions produced with a collection solution of 80 wt% ethanol, 20 wt% water, 0.005 wt% of Tergitol 15-S-9 and 20 mM SDS. The flow rate is 4 ml/h and the voltage is 2.8 kV. (A) Micrograph of the hexagonal lattices of emulsion droplets confirms size uniformity. (B) Droplet size distribution measured by dynamic light scattering. The diameter of the droplets is 1.02 ± 0.03 μm, and the polydispersity is 2.7 ± 0.1%.

Figure 7. Quantum dot encoded microspheres synthesized by electrospraying.

Figure 8. Schematic representation of a coaxial needle arrangement for controlled generation of either cell-bearing droplets or threads.

Figure 9. Comparison of publications of electrosprayed nanoparticles and electrospun nanofibers (based on Scifinder search).