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. 2013 Jul;260(7):1855-8.
doi: 10.1007/s00415-013-6892-4. Epub 2013 Mar 20.

Severity of coronary atherosclerosis and stroke incidence in 7-year follow-up

Wojciech Sobiczewski  1 , Marcin Wirtwein, Ewelina Trybala, Marcin Gruchala
Affiliations

Severity of coronary atherosclerosis and stroke incidence in 7-year follow-up

Wojciech Sobiczewski et al. J Neurol. 2013 Jul.

Abstract

The purpose of this prospective study was to investigate the association between the severity of coronary atherosclerosis in angiography and the risk of stroke in symptomatic coronary artery disease (CAD) patients without atrial fibrillation or atrial flutter. Associations between stroke and coronary artery disease were examined in 1,183 subjects without a history of stroke and who were referred for diagnostic coronary angiography. Association between stoke and coronary artery disease was determined using the COX proportional hazard regression model. During the follow-up period (mean 6.7 years), 50 strokes occurred. In the group with strokes there was a higher prevalence of multi-vessel coronary artery disease (62 vs. 46 %, p < 0.01). In the COX proportional hazard regression model, multi-vessel CAD was significantly associated with the stroke hazard ratio (HR) of 1.8 (CI 1.03-3.43), determined from a 7-year period of observation. Symptomatic patients with multi-vessel CAD are thus at a high risk of stroke development.

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References

    1. Yoo J, Yang JH, Choi BW, Kim YD, Nam HS, Choi HY, Cho HJ, Lee HS, Cha MJ, Choi D, Nam CM, Jang Y, Lee DH, Kim J, Heo JH. The frequency and risk of preclinical coronary artery disease detected using multichannel cardiac computed tomography in patients with ischemic stroke. Cerebrovasc Dis. 2012;33:286–294. doi: 10.1159/000334980. - DOI - PubMed
    1. Jensen JK, Medina H, Norgaard BL, Ovrehus KA, Jensen JM, Nielsen LH, Maurovich-Horvat P, Engel LC, Januzzi JL, Hoffmann U, Truong QA (2011) Association of ischemic stroke to coronary artery disease using computed tomography coronary angiography. Int J Cardiol 160:171–174 - PubMed
    1. Calvet D, Touze E, Varenne O, Sablayrolles JL, Weber S, Mas JL. Prevalence of asymptomatic coronary artery disease in ischemic stroke patients: the precoris study. Circulation. 2010;121:1623–1629. doi: 10.1161/CIRCULATIONAHA.109.906958. - DOI - PubMed
    1. Mendoza-Rodriguez V, Llerena LR, Rodriguez-de la Vega A, Rodriguez-Diaz Y. Volume of coronary calcified plaques by computed tomography and presence of significant stenosis by coronary angiography. Archivos de cardiologia de Mexico. 2010;80:181–186. - PubMed
    1. Olsen TS, Langhorne P, Diener HC, Hennerici M, Ferro J, Sivenius J, Wahlgren NG, Bath P. European stroke initiative recommendations for stroke management—update 2003. Cerebrovasc Dis. 2003;16:311–337. doi: 10.1159/000072554. - DOI - PubMed