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. 2013 Jun;30(6):439-45.
doi: 10.1007/s40266-013-0070-3.

Persistent use of analgesic medications in mild-to-moderate Alzheimer's disease

Adeline Gallini  1 , Virginie Gardette, Bruno Vellas, Maryse Lapeyre-Mestre, Sandrine Andrieu, Christine Brefel-Courbon; REAL.FR/DSA group
Collaborators, Affiliations

Persistent use of analgesic medications in mild-to-moderate Alzheimer's disease

Adeline Gallini et al. Drugs Aging. 2013 Jun.

Abstract

Background and objectives: Previous studies have reported a lower use of analgesics in patients with Alzheimer's disease (AD) than in non-AD elderly. To date, no study has focused on persistent analgesic use in patients with mild-to-moderate AD.

Methods: The "Réseau sur la maladie d'Alzheimer Français" (REAL.FR) cohort study enrolled community-dwelling patients with mild-to-moderate AD. Persistent analgesic use was defined as the consumption of at least one analgesic drug during two consecutive visits (6 months). Associated factors were identified in a nested case-control study.

Results: In REAL.FR, 595 patients were present during at least two consecutive visits [mean age = 77.5 ± 6.8 years, mini-mental state examination (MMSE) = 20.1 ± 4.2]. Prevalence of persistent analgesic use was 13.1 % (95 % CI = 10.4-15.9). The incidence of persistent analgesic use was 5.9/100 patient-years (95 % CI = 5.2-6.6). Women (adjusted odds ratio [OR] = 3.1, 95 % CI = 1.2-8.1), patients with musculoskeletal disorders (OR = 3.4, 95 % CI = 1.6-7.3) and patients treated with numerous medications (OR = 3.0, 95 % CI = 1.5-5.8) were more likely to use analgesics persistently. Statistically significant associations were found with disease duration and disease progression but not with AD severity at baseline.

Conclusions: Our results suggest a low use of analgesics in AD patients, which could vary with AD progression.

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Conflict of interest statement

Transparency statement

The authors have no conflicts of interest relevant to the content of this study.

References

    1. Scherder EJ, Bouma A. Is decreased use of analgesics in Alzheimer disease due to a change in the affective component of pain? Alzheimer Dis Assoc Disord. 1997 Sep;11(3):171–4. - PubMed
    1. Pickering G, Jourdan D, Dubray C. Acute versus chronic pain treatment in Alzheimer’s disease. Eur J Pain. 2006;10(4):379–84. - PubMed
    1. Bell JS, Laitinen M-L, Lavikainen P, et al. Use of strong opioids among community-dwelling persons with and without Alzheimer’s disease in Finland. Pain. 2011;152(3):543–7. - PubMed
    1. Bernabei R, Gambassi G, Lapane K, et al. Management of pain in elderly patients with cancer. SAGE Study Group. Systematic Assessment of Geriatric Drug Use via Epidemiology. JAMA. 1998;279(23):1877–82. - PubMed
    1. Closs SJ, Barr B, Briggs M. Cognitive status and analgesic provision in nursing home residents. Br J Gen Pract. 2004;54(509):919–21. - PMC - PubMed

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