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. 2013 Apr 22;52(17):4641-4.
doi: 10.1002/anie.201300841. Epub 2013 Mar 19.

Identification of cystathionine β-synthase inhibitors using a hydrogen sulfide selective probe

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Identification of cystathionine β-synthase inhibitors using a hydrogen sulfide selective probe

Megan K Thorson et al. Angew Chem Int Ed Engl. .

Abstract

Buzzing with activity: A hydrogen sulfide selective fluorogenic probe, 7-azido-4-methylcoumarin (AzMC), serves as a highly sensitive assay for cystathionine β-synthase activity, and is suitable for the high-throughput discovery of novel enzyme inhibitors.

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