Triple mode of action of flecainide in catecholaminergic polymorphic ventricular tachycardia
- PMID: 23512981
- PMCID: PMC3657388
- DOI: 10.1093/cvr/cvt059
Triple mode of action of flecainide in catecholaminergic polymorphic ventricular tachycardia
Comment in
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Triple mode of action of flecainide in catecholaminergic polymorphic ventricular tachycardia: reply.Cardiovasc Res. 2013 May 1;98(2):327-8. doi: 10.1093/cvr/cvt068. Epub 2013 Mar 27. Cardiovasc Res. 2013. PMID: 23536607 No abstract available.
Comment on
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Flecainide reduces Ca(2+) spark and wave frequency via inhibition of the sarcolemmal sodium current.Cardiovasc Res. 2013 May 1;98(2):286-96. doi: 10.1093/cvr/cvt012. Epub 2013 Jan 19. Cardiovasc Res. 2013. PMID: 23334259 Free PMC article.
References
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- Watanabe H, Chopra N, Laver D, Hwang HS, Davies SS, Roach DE, et al. Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans. Nat Med. 2009;15:380–383. doi:10.1038/nm.1942. - DOI - PMC - PubMed
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- van der Werf C, Kannankeril PJ, Sacher F, Krahn AD, Viskin S, Leenhardt A, et al. Flecainide therapy reduces exercise-induced ventricular arrhythmias in patients with catecholaminergic polymorphic ventricular tachycardia. J Am Coll Cardiol. 2011;57:2244–2254. doi:10.1016/j.jacc.2011.01.026. - DOI - PMC - PubMed
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- Watanabe H, van der Werf C, Roses-Noguer F, Adler A, Sumitomo N, Veltmann C, et al. Effects of flecainide on exercise-induced ventricular arrhythmias and recurrences in genotype-negative patients with catecholaminergic polymorphic ventricular tachycardia. Heart Rhythm. Advance Access published Dec 31, 2012, doi:10.1016/j.hrthm.2012.12.035 doi: - PMC - PubMed
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- Hilliard FA, Steele DS, Laver D, Yang Z, Le Marchand SJ, Chopra N, et al. Flecainide inhibits arrhythmogenic Ca2+ waves by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass. J Mol Cell Cardiol. 2010;48:293–301. doi:10.1016/j.yjmcc.2009.10.005. - DOI - PMC - PubMed
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- Liu N, Denegri M, Ruan Y, Avelino-Cruz JE, Perissi A, Negri S, et al. Short communication: flecainide exerts an antiarrhythmic effect in a mouse model of catecholaminergic polymorphic ventricular tachycardia by increasing the threshold for triggered activity. Circ Res. 2011;109:291–295. doi:10.1161/CIRCRESAHA.111.247338. - DOI - PubMed
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