Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2013 May 1;98(2):326-7.
doi: 10.1093/cvr/cvt059. Epub 2013 Mar 19.

Triple mode of action of flecainide in catecholaminergic polymorphic ventricular tachycardia

Comment

Triple mode of action of flecainide in catecholaminergic polymorphic ventricular tachycardia

Derek S Steele et al. Cardiovasc Res. .
No abstract available

PubMed Disclaimer

Comment in

Comment on

References

    1. Watanabe H, Chopra N, Laver D, Hwang HS, Davies SS, Roach DE, et al. Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans. Nat Med. 2009;15:380–383. doi:10.1038/nm.1942. - DOI - PMC - PubMed
    1. van der Werf C, Kannankeril PJ, Sacher F, Krahn AD, Viskin S, Leenhardt A, et al. Flecainide therapy reduces exercise-induced ventricular arrhythmias in patients with catecholaminergic polymorphic ventricular tachycardia. J Am Coll Cardiol. 2011;57:2244–2254. doi:10.1016/j.jacc.2011.01.026. - DOI - PMC - PubMed
    1. Watanabe H, van der Werf C, Roses-Noguer F, Adler A, Sumitomo N, Veltmann C, et al. Effects of flecainide on exercise-induced ventricular arrhythmias and recurrences in genotype-negative patients with catecholaminergic polymorphic ventricular tachycardia. Heart Rhythm. Advance Access published Dec 31, 2012, doi:10.1016/j.hrthm.2012.12.035 doi: - PMC - PubMed
    1. Hilliard FA, Steele DS, Laver D, Yang Z, Le Marchand SJ, Chopra N, et al. Flecainide inhibits arrhythmogenic Ca2+ waves by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass. J Mol Cell Cardiol. 2010;48:293–301. doi:10.1016/j.yjmcc.2009.10.005. - DOI - PMC - PubMed
    1. Liu N, Denegri M, Ruan Y, Avelino-Cruz JE, Perissi A, Negri S, et al. Short communication: flecainide exerts an antiarrhythmic effect in a mouse model of catecholaminergic polymorphic ventricular tachycardia by increasing the threshold for triggered activity. Circ Res. 2011;109:291–295. doi:10.1161/CIRCRESAHA.111.247338. - DOI - PubMed

Substances