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. 2013 Mar 18;23(3):265-7.
doi: 10.1016/j.ccr.2013.02.021.

ROS links glucose metabolism to breast cancer stem cell and EMT phenotype

Michael S Schieber  1 , Navdeep S Chandel
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ROS links glucose metabolism to breast cancer stem cell and EMT phenotype

Michael S Schieber et al. Cancer Cell. .
Free article

Abstract

Cancer stem cells display an epithelial-mesenchymal transition phenotype and are resistant to current therapies. In this issue of Cancer Cell, Dong and colleagues demonstrate that these phenotypes in basal-like breast cancer are promoted by a metabolic switch to glucose metabolism, resulting in decreased reactive oxygen species levels.

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