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. 2012 Dec 13;17(12):14899-907.
doi: 10.3390/molecules171214899.

Two new oleanane-type triterpenoids from Platycodi Radix and anti-proliferative activity in HSC-T6 cells

Qin Zhan  1 , Feng Zhang, Lianna Sun, Zhijun Wu, Wansheng Chen
Affiliations

Two new oleanane-type triterpenoids from Platycodi Radix and anti-proliferative activity in HSC-T6 cells

Qin Zhan et al. Molecules. .

Abstract

Two new oleanane-type triterpenoids, named platycodonoids A and B (1, 2), together with five known saponins, including platycodin D (3), deapioplatycodin D (4), 3-O-β-D-glucopyranosyl polygalacic acid (5), 3-O-β-D-glucopyranosyl platycodigenin (6) and polygalacin D (7), were isolated from the roots of Platycodon grandiflorum. On the basis of spectral data and chemical evidence, the structures of the new compounds were elucidated as 2β,3β,23,24-tetrahydroxy-28-nor-olean-12-en-16-one (1) and 2β,3β,23,24- tetrahydroxy-28-nor-olean-12-en-16-one-3-O-β-D-glucopyranoside (2). Compounds 1-7 were evaluated for their in vitro anti-proliferative activity against the HSC-T6 cell line.

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Figures

Figure 1
Figure 1
Structures of compounds 1−7.
Figure 2
Figure 2
Key 1H-1H COSY (bold lines) and HMBC (H→C) correlations of compound 1.
Scheme 1
Scheme 1
The plausible biogenetic origin of compounds 1 and 2.
See this image and copyright information in PMC

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