Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1990 Jun 1;171(6):2147-52.
doi: 10.1084/jem.171.6.2147.

Molecular cloning of CD31, a putative intercellular adhesion molecule closely related to carcinoembryonic antigen

D L Simmons  1 , C Walker, C Power, R Pigott
Affiliations

Molecular cloning of CD31, a putative intercellular adhesion molecule closely related to carcinoembryonic antigen

D L Simmons et al. J Exp Med. .

Abstract

cDNA clones encoding CD31 have been isolated by transient expression. The sequence of CD31 expressed on human umbilical vein endothelial cells (HUVEC) is identical to that expressed on the monocyte-like cell line HL60. In HUVEC. CD31 is concentrated in regions of cell-cell contacts. CD31 is a member of the Ig superfamily and is most closely related to the carcinoembryonic antigen CEA, consisting of four contiguous C2 domains. The localization of CD31 to regions of cell-cell contacts, and the sequence similarity to CEA, a known intercellular adhesion molecule (ICAM), strongly suggest that CD31 may function as an ICAM, possibly mediating endothelial cell-cell contacts and also promoting interactions between leukocytes and endothelial cells.

PubMed Disclaimer

References

    1. J Clin Invest. 1973 Nov;52(11):2745-56 - PubMed
    1. Science. 1981 Oct 9;214(4517):149-59 - PubMed
    1. Proc Natl Acad Sci U S A. 1983 Feb;80(3):726-30 - PubMed
    1. Methods Enzymol. 1983;91:524-45 - PubMed
    1. Nucleic Acids Res. 1986 Jun 11;14(11):4683-90 - PubMed

Publication types

Substances

Associated data