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Comment
. 2013 Apr;62(4):1024-5.
doi: 10.2337/db12-1789.

ContRac1ion-mediated glucose uptake: a central role for Rac1

Leonidas S Lundell  1 , Anna Krook
Affiliations
Comment

ContRac1ion-mediated glucose uptake: a central role for Rac1

Leonidas S Lundell et al. Diabetes. 2013 Apr.
No abstract available

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Figures

FIG. 1.
FIG. 1.
Possible upstream and direct regulators of Rac1 activity. Contraction stimulates GLUT4 exocytosis by activating a range of different molecules, including AMPK, PKC, and TBCD1. Evidence presented by Sylow et al. (1) indicates that AMPK is not involved in Rac1 activation. Other possible pathways include TBC1D1 and PKC. Rac1 cycling between active, GTP bound state and inactive, GDP bound state is another possible node by which Rac1 regulates GLUT4 exocytosis.
See this image and copyright information in PMC

Comment on

References

    1. Sylow L, Jensen TE, Kleinert M, et al. Rac1 is a novel regulator of contraction-stimulated glucose uptake in skeletal muscle. Diabetes 2013;62:1139–1151 - PMC - PubMed
    1. Wallberg-Henriksson H, Holloszy JO. Contractile activity increases glucose uptake by muscle in severely diabetic rats. J Appl Physiol 1984;57:1045–1049 - PubMed
    1. Wallberg-Henriksson H, Constable SH, Young DA, Holloszy JO. Glucose transport into rat skeletal muscle: interaction between exercise and insulin. J Appl Physiol 1988;65:909–913 - PubMed
    1. Koistinen HA, Galuska D, Chibalin AV, et al. 5-amino-imidazole carboxamide riboside increases glucose transport and cell-surface GLUT4 content in skeletal muscle from subjects with type 2 diabetes. Diabetes 2003;52:1066–1072 - PubMed
    1. Hawley SA, Selbert MA, Goldstein EG, Edelman AM, Carling D, Hardie DG. 5′-AMP activates the AMP-activated protein kinase cascade, and Ca2+/calmodulin activates the calmodulin-dependent protein kinase I cascade, via three independent mechanisms. J Biol Chem 1995;270:27186–27191 - PubMed