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Controlled Clinical Trial
. 2013 Jul-Aug;37(4):631-6.
doi: 10.1016/j.clinimag.2013.02.001. Epub 2013 Mar 20.

Clinical MRI for iron detection in Parkinson's disease

Maija Rossi  1 , Hanna Ruottinen, Seppo Soimakallio, Irina Elovaara, Prasun Dastidar
Affiliations
Controlled Clinical Trial

Clinical MRI for iron detection in Parkinson's disease

Maija Rossi et al. Clin Imaging. 2013 Jul-Aug.

Abstract

We studied nonheme iron in Parkinson's disease (PD) using clinically available MRI in 36 patients and 21 healthy volunteers. The subjects underwent thorough clinical investigation, including 3-T MRI. Quantitative R2* was able to reflect symptoms of PD. In addition, the clinically used susceptibility-weighted imaging differentiated between controls and patients, whereas T2-weighted imaging did not. Disease-related changes were present not only in substantia nigra but also in globus pallidus. Such changes are associated with neurodegeneration, reflecting the severity of motor impairment.

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