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Review
. 2013 Oct:19:312-22.
doi: 10.1016/j.meegid.2013.03.005. Epub 2013 Mar 21.

HIV mother-to-child transmission: a complex genetic puzzle tackled by Brazil and Argentina research teams

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Review

HIV mother-to-child transmission: a complex genetic puzzle tackled by Brazil and Argentina research teams

R Celerino da Silva et al. Infect Genet Evol. 2013 Oct.

Abstract

Human immunodeficiency virus (HIV) mother-to-child transmission is a complex event, depending upon environmental factors and is affected by host genetic factors from mother and child, as well as viral genetic elements. The integration of multiple parameters (CD4 cell count, virus load, HIV subtype, and host genetic markers) could account for the susceptibility to HIV infection, a multifactorial trait. The goal of this manuscript is to analyze the immunogenetic factors associated to HIV mother-to-child transmission, trying to unravel the genetic puzzle of HIV mother-to-child transmission and considering the experience in this topic of two research groups from Brazil and Argentina.

Keywords: HIV; Host genome; Immunogenetics markers; Mother-to-child transmission; Protection; Susceptibility.

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