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. 2013 Feb 1;2(2):e23038.
doi: 10.4161/onci.23038.

Macrophages: Good guys in colorectal cancer

Sofia Edin  1 , Maria L Wikberg, Per-Arne Oldenborg, Richard Palmqvist
Affiliations

Macrophages: Good guys in colorectal cancer

Sofia Edin et al. Oncoimmunology. .

Abstract

Macrophages play a complex role in tumor progression since they can exert both tumor-preventing (M1 macrophages) and tumor-promoting (M2 macrophages) activities. In colorectal carcinoma (CRC), at odds to many other cancers, macrophage infiltration has been correlated with an improved patient survival. In a recent study, we have evaluated the distribution of M1 and M2 macrophage subtypes in CRC and their impact on patient prognosis.

Keywords: CpG island methylator phenotype; colorectal cancer; macrophage subtypes; microsatellite instability; prognosis.

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Figures

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Figure 1. Distribution of M1 and M2 macrophages in colorectal carcinoma, and their potential role in tumor control.
See this image and copyright information in PMC

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