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. 2013 Mar 1;1(1):34-40.
doi: 10.1007/s40124-012-0003-3. Epub 2012 Dec 22.

Pediatric Acute Kidney Injury: Different From Acute Renal Failure But How And Why

Prasad Devarajan  1
Affiliations

Pediatric Acute Kidney Injury: Different From Acute Renal Failure But How And Why

Prasad Devarajan. Curr Pediatr Rep. .

Abstract

Acute kidney injury [AKI] refers to a clinical syndrome encompassing various etiologies and occurring in a variety of clinical settings, with manifestations ranging from subtle biochemical and structural changes, to minimal elevation in serum creatinine, to anuric renal failure. Understanding the spectrum of AKI and the importance of the early pre-clinical damage stage has resulted in an improved ability to define and stage pediatric AKI, to understand the AKI-to-CKD transition, and harness novel damage biomarkers to predict AKI and its adverse outcomes. These concepts are expanded upon in this review, with an emphasis on publications from the past three years.

Keywords: acute kidney injury; acute renal failure; biomarkers; neutrophil gelatinase-associated liopcalin.

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Conflict of interest statement

Disclosure: No potential conflicts of interest relevant to this article were reported.

References

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